Publications

Preprints

Zhang Z, Holton M, Ferrer DM, Tripp AD, Richter A, Dixit PD, Urtecho G. "Metagenome-scale Modeling to Assess Microbiome Metabolic Complementarity for Precision Microbiota Transplantation Therapies" 2026. bioRxiv. doi:10.64898/2026.05.15.725570

2026

Guillaume Urtecho*, Liyuan Liu*, Charlotte Rochereau*, Simon Kozlov*, Jiahui Zhao, Jasmine Wang, Yiming Huang, Yiming Qu, Zetian Zhang, Tomasz Blazejewski, Avi Swartz, Sergey Ovchinnikov*, and Harris H. Wang*. “Towards life with a 19-amino-acid alphabet via generative AI design”. 2026. Science. 392,eaeb5171. 

2025

Gurdip Uppal, Guillaume Urtecho, Miles Richardson, Isin Y. Comba, Jeongchan Lee, Thomas Moody, Harris H. Wang, and Georg K. Gerber. "MCSPACE: inferring microbiome spatiotemporal dynamics from high-throughput co-localization data." 2025. Microbiome.

Richardson, Miles, Shijie Zhao, Liyuan Lin, Ravi U. Sheth, Yiming Qu, Jeongchan Lee, Thomas Moody, Deirdre Ricaurt, Yiming Huang, Florencia Velez-Cortes, Guillaume Urtecho, & Harris Wang. (2025). SAMPL-seq reveals micron-scale spatial hubs in the human gut microbiome. Nature Microbiology 10, no. 2: 527-540. 

Guillaume Urtecho, Thomas Moody, Yiming Huang, Ravi U. Sheth, Miles Richardson, Hélène Descamps, Andrew Kaufman, Opeyemi Lekan, Florencia Velez-Cortes, Deirdre Ricaurte, Travis E. Gibson, Georg K. Gerber, Christoph A. Thaiss, & Harris H. Wang. (2025). Spatiotemporal dynamics during niche remodeling by super-colonizing microbiota in the mammalian gut. Cell Systems. 2025. 15(11), 1002-1017. 

2024 and sooner

Wang, Qian, Yicheng Guo, Logan T. Schwanz, Ian A. Mellis, Yiwei Sun, Yiming Qu, Guillaume Urtecho, Riccardo Valdez, Emily Stoneman, Aubree Gordon, Harris H. Wang, Lihong Liu, and David D. Ho. "SARS-CoV-2 Omicron BA.2.87.1 exhibits higher susceptibility to serum neutralization than EG.5.1 and JN.1." (2024) Emerging Microbes & Infections, 13(1). https://doi.org/10.1080/22221751.2024.2359004. 

Ho, Chi-Lee, Michael Gilbert, Guillaume Urtecho, Hyungjoo Lee, David Drew, Samuel Klempner, Jin Cho, Thomas Ryan, Naryan Rustgi, Hyuk Lee, Jeeyun Lee, Alexander Caraballo, Marina Magicheva-Gupta, Carmen Rios, Yuen-Yi Tseng, Jeremy Davis, Daniel Chung, Andrew Chan, Harris Wang, and Sandra Ryeom. "Stool protein mass spectrometry identifies biomarkers for the early detection of diffuse-type gastric cancer. Cancer Prevention Research. 2024. https://doi.org/10.1158/1940-6207.CAPR-23-0449.

Guillaume Urtecho* & Kimberly D. Insigne*, Arielle D. Tripp, Marcia Brinck, Nathan B. Lubock, Hwangbeom Kim, & Sriram Kosuri. Genome-wide Functional Characterization of Escherichia coli Promoters and Regulatory Elements Responsible for their Function. eLife. 2023. https://doi.org/10.7554/eLife.92558.1. (Corresponding Author)

Ilya Andreev, Kamilla M. E. Laidlaw, Simone M. Giovanetti, Guillaume Urtecho, Daniel Shriner, Joshua S.  Bloom, Chris Macdonald, & Meru J. Sadhu. "Discovery of a

rapidly evolving yeast defense factor, KTD1, against the secreted killer toxin K28". Proceedings of the National Academy of Sciences 120.8 (2023): e2217194120.

Timothy C. Yu* & Winnie L. Liu*, Marcia Brinck, Jessica E. Davis, Jeremy Shek, Grace Bower, Tal Einav, Kimberly D. Insigne, Rob Phillips, Sriram Kosuri, & Guillaume Urtecho. Multiplexed characterization of rationally designed promoter architectures deconstructs combinatorial logic for IPTG-inducible systems. 2021. Nature Communications. 12, 325 (2021). https://doi.org/10.1038/s41467-020-20094-3. (Senior & Corresponding Author)

Guillaume Urtecho, Danielle E. Campbell, David M. Hershey, Fatima A. Hussain, Rachel J. Whitaker, & George A. O'Toole. Discovering the Molecular Determinants of Phaeobacter inhibens susceptibility to Phaeobacter phage MD18. 2020. mSphere. 5 (6) e00898-20. doi:10.1128/mSphere.00898-20. (Corresponding Author)

Guillaume Urtecho, Arielle D. Tripp, Kimberly D. Insigne, Hwangbeom Kim, & Sriram Kosuri. Systematic Dissection of Sequence Elements Controlling σ70 Promoters Using a Genomically Encoded Multiplexed Reporter Assay in Escherichia coli. 2018. Biochemistry. 58 (11), 1539-1551DOI: 10.1021/acs.biochem.7b01069. (Special issue: The Chemistry of Synthetic Biology)

Ravi Maruthachalam, Mohan Prem Anand Marimuthu, Ek Han Tan, Shamoni Maheshwari, Isabelle M. Henry, Brenda Marin-Rodriguez, Guillaume Urtecho, Jie Tan, Kristina Thornhill, Fan Zhu, Aneesh Panoli, Venkatesan Sundaresan, Anne B. Britt, Luca Comai, & Simon W. L. Chan. A Haploid Genetics Toolbox for Arabidopsis Thaliana. 2014. Nature Communications, 5:5334.